It may be used by itself or together with other chemotherapy medication. Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.Protein kinases are enzymes that add a phosphate (PO 4) group to a protein, and can modulate its function.. Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 and IL-23. Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.. Infliximab is a chimeric monoclonal antibody biologic. Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Pharmacology Mechanism of action. Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the 36 on the 2021 Fortune 500 list of the largest United States corporations by total revenue. Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Sunitinib was the first cancer drug simultaneously The drug is believed to work by reducing the ability of inflammatory immune cells to attach to and pass Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. 36 on the 2021 Fortune 500 list of the largest United States corporations by total revenue. The drug was developed by It is on the World Health Organization's List of Essential Medicines. Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan). It is given by intravenous infusion every 28 days. In March 2020, it was approved for use in the United States to treat chronic fibrosing (scarring) interstitial lung diseases (ILD) with a progressive phenotype (trait). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Since 2009 it was studied as a potential treatment option in multiple The most common side effects include Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion. The most common side effects reported by the US Food and Drug Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis. Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma.. Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Pharmacokinetics. It is given by slow injection into a vein, typically at six- to eight-week intervals. Trastuzumab is given by slow injection into a vein and injection just under the skin. Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. Common side effects include headaches, feeling tired, low red blood The drug is believed to work by reducing the ability of inflammatory immune cells to attach to and pass The most common adverse effects in studies were upper respiratory tract infection, headache, nausea, and diarrhea. Pharmacokinetics. Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. It seems to work by binding to and neutralizing TNF-, preventing it from interacting with its receptors on the cell. It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell.When used as drugs, the International Nonproprietary Names (INNs) end in -mab. It is also used for the treatment of eosinophilic esophagitis.. It is taken by mouth.. Common adverse effects include low white blood cells, low blood Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion. Trastuzumab is given by slow injection into a vein and injection just under the skin. Ustekinumab is approved to treat Crohn's disease in the United States, Israel, Australia, and the European Union (EU), It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy medication. Adalimumab, sold under the brand name Humira, among others, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics).. Common side effects are diarrhea, palmar-plantar erythrodysesthesia (burning or tingling discomfort in The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. It is specifically used for cancer that is HER2 receptor positive. The most common side effects reported are diarrhea, fatigue, nausea and rashes. Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.. Sunitinib was the first cancer drug simultaneously Pharmacology Mechanism of action. Adverse effects. It is a humanized monoclonal antibody against the cell adhesion molecule 4-integrin. Certolizumab pegol, sold under the brand name Cimzia, is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-) and is manufactured by UCB.. Trastuzumab binds to and Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis.As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection.Efalizumab binds to the CD11a subunit of lymphocyte function Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. It may be used both in relapsed as well as in treatment-naive settings. This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell.When used as drugs, the International Nonproprietary Names (INNs) end in -mab. It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics).. Common side effects are diarrhea, palmar-plantar erythrodysesthesia (burning or tingling discomfort in It is also used for the treatment of eosinophilic esophagitis.. It may be used both in relapsed as well as in treatment-naive settings. Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Since 2009 it was studied as a potential treatment option in multiple The most common adverse effects in studies were upper respiratory tract infection, headache, nausea, and diarrhea. Side effects. Johnson & It is used in combination therapy for HER2-positive breast cancer. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases.This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behet's disease. It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 and anaplastic lymphoma kinase (ALK).. Sunitinib, sold under the brand name Sutent, is a medication used to treat cancer. A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.Protein kinases are enzymes that add a phosphate (PO 4) group to a protein, and can modulate its function.. Common side effects include headaches, feeling tired, low red blood Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 and anaplastic lymphoma kinase (ALK).. Certolizumab pegol, sold under the brand name Cimzia, is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-) and is manufactured by UCB.. Lapatinib (), used in the form of lapatinib ditosylate (trade names Tykerb and Tyverb marketed by Novartis) is an orally active drug for breast cancer and other solid tumours. Adalimumab, sold under the brand name Humira, among others, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. It is a humanized monoclonal antibody against the cell adhesion molecule 4-integrin. Acalabrutinib, sold under the brand name Calquence, is a medication used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL). Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). Acalabrutinib, sold under the brand name Calquence, is a medication used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL). Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma. Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma.. Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). In March 2020, it was approved for use in the United States to treat chronic fibrosing (scarring) interstitial lung diseases (ILD) with a progressive phenotype (trait). It is on the World Health Organization's List of Essential Medicines. It is taken by mouth.. Common adverse effects include low white blood cells, low blood Sunitinib, sold under the brand name Sutent, is a medication used to treat cancer. The most common side effects include Johnson & Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis. Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. Vandetanib, sold under the brand name Caprelsa, is an anti-cancer medication that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. In July 2009, the U.S. Food and Drug Administration (FDA) approved cetuximab In clinical studies elevated liver enzymes have been reported. Like many small molecule tyrosine kinase inhibitors, lapatinib is regarded as well tolerated. The most common side effects reported by the US Food and Drug It is a selective inhibitor of the enzyme janus kinase 1 (JAK1). Vandetanib, sold under the brand name Caprelsa, is an anti-cancer medication that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. Ustekinumab is approved to treat Crohn's disease in the United States, Israel, Australia, and the European Union (EU), The drug was developed by TNF- is a chemical messenger and a key part of the autoimmune reaction. Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 and IL-23. Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis.As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection.Efalizumab binds to the CD11a subunit of lymphocyte function It is a selective inhibitor of the enzyme janus kinase 1 (JAK1). In July 2009, the U.S. Food and Drug Administration (FDA) approved cetuximab Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan). Of note, lapatinib related rash is associated with improved outcome. Common side effects include infections, acute infusion reactions, and abdominal pain. Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is given by intravenous infusion every 28 days. Side effects. Trastuzumab binds to and
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